Acupressure practitioners use their fingers palms elbows or feet or special devices to apply pressure to acupoints on the body's meridians. Sometimes acupressure also involves stretching or acupressure massage Arthritis. Some studies suggest that acupressure releases endorphins and promotes anti-inflammatory effects helping with certain types of arthritis. Depression and anxiety. More than one study suggests that fatigue and mood may improve from the use of acupressure. Better designed trials are needed to be sure.